The crash happened at about 7:50 p.m. on Monday, May 30, on Route 32 near Meeting House Hill Road in the New London County town of Franklin, according to Connecticut State Police.
A 2010 Honda Accord EX-L was traveling north on Route 32 when it failed to maintain its lane and traveled into the southbound lane, striking a southbound 2017 Lexus NX2, police said.
The driver of the Honda, identified as 24-year-old Jullian Raul Parrilla, of Windham, was pronounced dead at the hospital, police said.
Authorities said a passenger in the Honda, identified as 25-year-old Andre Shamar Wade, of Willimantic, was pronounced dead at the scene.
Police said a 21-year-old Willimantic man who was a passenger in the Honda was hospitalized for suspected minor injuries, and the driver of the Lexus, a 30-year-old woman from Mount Sinai, New York, was hospitalized for suspected serious injuries.
Authorities asked any witnesses to call Connecticut State Police at 860-465-5400.
Click here to follow Daily Voice Windham-Willimantic and receive free news updates.